Suplement do nr-u 1/2003

Ocena korelacji między wynikami perymetrii komputerowej a zmianami w stężeniu endoteliny-1 we krwi u chorych na jaskrę pierwotną otwartego kąta po teście ochłodzenia

Evaluation of correlation between static perimetry results and changes in endothelin-1 plasma levels after cold-pressor test in primary open-angle glaucoma patients

Barbara Terelak-Borys1, Krystyna Czechowicz-Janicka1,
Małgorzata Radzikowska2

1Klinika Okulistyki Centrum Medycznego Kształcenia Podyplomowego w Warszawie
Kierownik: prof. dr hab. med. Krystyna Czechowicz-Janicka
2Zakład Neuroendokrynologii Centrum Medycznego Kształcenia Podyplomowego w Warszawie
Kierownik: prof. dr hab. med. Bogusława Baranowska


Summary: Vasospastic reactions are considered to be one of the risk factors in the pathogenesis of glaucoma and they may lead to visual field defects via disturbing autoregulatory mechanisms of blood flow in the optic nerve head. Endothelin-1 (ET-1) is the most potent vasospastic mediator, produced by vascular endothelium, which is responsible for autoregulation. In this study we measured ET-1 plasma levels in basal conditions and after cold-pressor test in three groups of subjects: 1) primary openangle, high-tension glaucoma patients, 2) normal-tension glaucoma patients, 3) healthy persons, and tried to correlate changes in ET-1 plasma levels with static perimetry results after this test. Significant elevation of ET-1 plasma levels occurred in all the three groups examined after cold-pressor test. This elevation was significantly highest in normal-tension glaucoma patients and associated with significant decrease of mean sensivity (MS) value in the static perimetry. Results of the study indicate that ET-1 may be involved in the vasospastic reactions, provoked by cold, and these reactions are strongest in normal-tension glaucoma patients. The results also suggest, that vasospastic effects of ET-1 may lead to visual field damage in normal-tension glaucoma patients.

Keywords: glaucoma, endothelin-1, vasospastic reactions, static perimetry.


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