Leczenie neowaskularyzacji podsiatkówkowej w przebiegu zwyrodnienia plamki związanego z wiekiem w Klinice Chorób Oczu w Bydgoszczy w latach 2006-2008
Subretinal Neovascularization Treatment Due to Age-related Macular Degeneration in Ophthalmology Department of the Collegium Medicum in Bydgoszcz Since 2006 to 2008
Magdalena Grześk, Małgorzata Seredyka-Burduk, Józef Kałużny
Katedra i Klinika Chorób Oczu Uniwersytetu im. Mikołaja Kopernika w Toruniu Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy Kierownik: prof. dr hab. n. med. Józef Kałużny
Summary: Introduction: Subretinal neovascularization due to age-related macular degeneration is the most common reason of irreversible blindness in patients aged fifty. With becoming older the risk of the retinal degeneration increase. Taking under consideration fact, that societies became older, people lifetime became longer and longer, every day there is more and more people who should be treated. The most common risk factors of age-related macular degeneration seems to be cardio-vascular diseases, diabetes and smoking. Vascular endothelial growth factor is thought to play very important role in subretinal neovascularization etiology.
Purpose: To compare results of intravitreal pegaptanib injection versus photodynamic injection with verteporfirin as a primary treatment of subretinal neovasularization due to age-related macular degeneration. Material and method: The eyes were assigned to the group treated with the use of the PDT or intravitreal pegaptanib injection. The treatment was established up to the type of the degeneration. We treated 97 patients with AMD. Photodynamic therapy were made in 65 patients (74 eyes) (group I), 32 patients (43 eyes) were given intravitreal pegaptanib injections (group II). We have made 205 PDT (on average 2.76 ± 2.35) and 176 intravitreal injections (on average 5.18 ± 2.55). The most of the patients were women. VA before treatment were on average 0.35 ± 0.21 (0.04 to 0.9) in I group and in II group 0.42 ± 0.23 (0.1 to 1,0). After treatment VA decreased in both I and II group and were 0.30 ± 0.22 (0.02 to 0.9) in I group and 0.37 ± 0.27 (0.1 to 1.0) in II group.
Conclusions: In most cases there were clinical stabilization, in spite of the fact that in fluorescein angiography diameter of the retinal damage increased. Both patients and their patients are waiting for new, safe medicine, which diminish the risk of the vision loss.
Słowa kluczowe: neowaskularyzacja podsiatkówkowa - CNV, zwyrodnienie plamki związane z wiekiem - AMD.
Keywords: choroidal neovascularization - CNV, age-related macular degeneration - AMD.