Rak płaskonabłonkowy spojówki - etiologia, obraz kliniczny i metody leczenia
Squamous Cell Carcinoma of the Conjunctiva - Etiology, Clinical Picture and Treatment Methods
Krzysztof Mika, Arkadiusz Pogrzebielski, Monika Węglarz, Bożena Romanowska-Dixon
Klinika Okulistyki i Onkologii Okulistycznej Katedry Okulistyki Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie Kierownik: dr hab. n. med. Bożena Romanowska-Dixon
Summary: Analysis of patient cases with histopathologically confirmed SCC of the conjunctiva and evaluation of probable causes, clinical picture, diagnostics and malignancy treatment methods. Squamous cell carcinoma of the conjunctiva (SCCC) is defined as a malignant epithelial neoplasm characterized by basement membrane invasion. SCCC is a very rarely occurring neoplasia but it is more common in equatorial regions of the world. Environmental factors are suspected to influence the SCCC occurrence, including: ultraviolet radiation, human papilloma virus infection, immunodeficiency and others. The most often treatment is surgical excision with limbal-conjunctival autograft transplantation with adjuvant 95% alcohol epitheliectomy. Cryotherapy and additional Ru-106 brachytherapy can be helpful. Adjuvant 0.02 % Mitomycin C (antymitotic factor) is also used in some centers. The most recent studies focus on Retinoic Acid and Interferon ? as antyangiogenic and anti-inflammatory factors. Usage of these two drugs is still under clinical trials.
Keywords: squamous cell carcinoma of the conjunctiva (SCCC), environmental hazards suspected to influence the SCCC development, current treatment methods, new alternatives in treatment methods.