Wydanie 2/2003

Niewydolności rąbkowych komórek macierzystych rogówki - obraz kliniczny

Clinical diagnosis of limbal stem cell deficiency

Edward Wylęgała

Oddział Okulistyczny Okręgowego Szpitala Kolejowego w Katowicach Ligocie Ordynator: dr med. Edward Wylęgała


Summary: The corneal epithelium is maintained by limbal stem cell. These cells migrate onto the basal and suprabasal part of the cornea epithelium. The limbal stem cells have long life span, slow cycling and poor differentiation. Limbal stem cell deficiency (LSCD) is characterized by conjunctival epithelial ingrowth, vascularisation and chronic inflammation. There are many corneal pathology: ulcers, recurrent erosion, persistent epithelial defects that are caused by LSCD. Conjunctivilisation is a clinical sign sine qua non in diagnostic of this pathology. Disorders with LSCD could be primary and secondary. The first group contains aniridia, sclerocornea and congenital erythrokeratodermia and latter: trauma: eg chemical burns, thermal burns, and inflammatory origin disorders (Stevens Johnson syndrome, ocular pemphigoid and contact lens induced keratopathy etc). Clinical management includes limbal transplantation from fellow eye, from living related donors or from cadaver donors.

Keywords: limbal stem cell, corneal surface disorders, limbal stem cell transplantation


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