Wydanie 4/2014
str. 22

Wpływ kwasu acetylosalicylowego na rozwój zwyrodnienia plamki związanego z wiekiem

Effect of Acetylsalicylic Acid on the Development of Age-related Macular Degeneration

Katarzyna Michalska-Małecka1,2, Agnieszka Regucka2, Bartłomiej Jewiarz2, Dorota Śpiewak2, Katarzyna Witek2

1Klinika Okulistyki Katedry Okulistyki Śląskiego Uniwersytetu Medycznego w Katowicach
Kierownik: prof. dr hab. n. med. Ewa Mrukwa-Kominek
2 Klinika Okulistyki, Uniwersyteckie Centrum Okulistyki i Onkologii Samodzielnego Publicznego Szpitala Klinicznego Śląskiego Uniwersytetu Medycznego w Katowicach
Kierownik: prof. dr hab. n. med. Ewa Mrukwa-Kominek


Summary: Aspirin (acetylsalicylic acid) is currently the most commonly used drug in the world due to its’ anti-inflammatory, analgesic, and antipyretic properties. It also inhibits platelets aggregation. It is estimated that more than one hundred billion tablets is taken each year worldwide. Recently there have been many reports on the effect of the aspirin on one of the most common eye diseases – age-related macular degeneration. Age-related macular degeneration is the effect of several processes occurring within the outer retinal layers: lipofuscin genesis, drusen genesis, chronic local inflammation and neovascularization.
In this article we quote the results of the most important studies on the effects of aspirin on the development of age-related macular degeneration. The authors of some of the listed studies show a higher risk wet form of age-related macular degeneration development in patients taking aspirin. The other studies did not show any association between drug use and the development of age-related macular degeneration. In one study the authors demonstrated that the use of aspirin and statins in patients diagnosed with age-related macular degeneration reduced risk of developing choroidal neovascularization. We present the mechanisms of action of aspirin affecting the pathogenesis of age-related macular degeneration, and indicate both adverse and protective aspects of its use in patient with various forms of age-related macular degeneration.
Considering many often conflicting reports on the effect of aspirin on the development of early and late age-related macular degeneration it is difficult to obtain clear answer whether patient with age-related macular degeneration should or should not take aspirin.
Based on many studies it seems that condescending aspirin treatment of cardiovascular diseases in patient with early forms of age-related macular degeneration and geographic atrophy should not be stopped.
In patients with neovascular form of age-related macular degeneration aspirin significantly increases risk of choroidal and vitreous hemorrhage, therefore dosage and the type of anticoagulant therapy should be deeply considered.

Słowa kluczowe: kwas acetylosalicylowy, zwyrodnienie plamki związane z wiekiem.

Keywords: acetylsalicylic acid, age-related macular degeneration.


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