Wydanie 1/2010

Osmolarność - aktualne spojrzenie na nowy standard w diagnostyce zaburzeń filmu łzowego

Osmolarity - Current View on New Standard in Tear Film Disorders Diagnostics

Anna M. Ambroziak, Ewa Langwińska-Wośko, Magdalena Korwin

Katedra i Klinika Okulistyki II Wydziału Lekarskiego Warszawskiego Uniwersytetu Medycznego Samodzielny Publiczny Kliniczny Szpital Okulistyczny w Warszawie Kierownik: prof. dr hab. n. med. Jerzy Szaflik

Summary: Dry eye is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear instability, with potential damage to the ocular surface. It is accompanied by increased tears osmolarity and inflammation of the ocular surface. But epidemiology is still unclear and depend of population, age, and specially of dry eye assessment ? criteria for the DE diagnosis, Polish study shows from near 10% to 18%. DE is not a single disease but multifactorial, multisymptomatic complex syndrome. What?s more the syndrome can?t be associated with only one layer: lipid, aquaeus or mucous layer. Tests are used for various purposes: To diagnose dry eye in everyday clinical practice. To assess special parameters in a clinical trial. To characterize dry eye as part of a clinical syndrome, e.g., as in the harmonized Sjogren?s syndrome classification criteria. To follow the natural history of the disorder. This opportunity is limited for dry eye, because treatment is so common in the population. However, the natural history of treated patients is also of interest, although they represent a heterogeneous population. Currently, the best test recommended by FDA is tear osmolarity measurement. The place of tear osmolarity measurement in dry eye diagnosis is well established, and its adoption has several attractions. There is considerable value in assessing a parameter that is directly involved in the dry eye mechanism.

Słowa kluczowe: film łzowy, suche oko, diagnostyka zespołu suchego oka, osmolarność.

Keywords: tear film, dry eye, diagnosis of dry eye syndrome, osmolarity.