Wydanie 2/2007

Zaburzenia filmu łzowego jako czynnik ryzyka choroby przeszczepu rogówki

Tear Film Disturbances as a Risk Factor for Corneal Graft Failure

Joanna Murawska, Jarosława Krajka-Lauer, Paweł Lipowski, Grażyna Madajewska, Krystyna Raczyńska

Katedra i Klinika Chorób Oczu Akademii Medycznej w Gdańsku
Kierownik: prof. dr hab. n. med. Krystyna Raczyńska

Summary: The aim of the study was to analyze the influence of the dry eye syndrome on corneal graft rejection.
Materials and methods: A prospective study has been conducted in the Department of Ophthalmology of Medical University of Gdansk since November 2006. 25 patients (25 eyes) were included in this study (9 men, 16 women) aged 19-86, who underwent penetrating keratoplasty. Patients were divided into 3 groups: 1 – without high risk factors for an endothelial allograft rejection, 2 – patients classified for keratoplasty due to severe corneal complications due to dry eye syndrome and 3 – the rest of the patients. All patients underwent an ophthalmological examination and typical dry eye diagnostic tests before corneal transplantation and three times within the first 6 postoperative months.
Results:. 1 group was composed of 11 eyes, 2 group – 2 eyes, 3 group – 12 eyes. During 6 months follow-up episodes of corneal graft rejection were observed in 5 patients (3 eyes from 1 group, one from 2 and one from 3 group).
Conclusions: Dry eye syndrome may be important isolated risk factor for corneal graft failure. Patients should be informed about this possible complication before corneal transplantation. Patients with underlying dry eye should receive special ophthalmological care after keratoplasty.

Keywords: corneal graft failure, corneal graft rejection, corneal transplantation, dry eye syndrome, keratoplasty, tear film insufficiency.


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