Wydanie 1/2005

Ocena oraz porównanie filmu łzowego u kobiet w okresie postmenopauzalnym - niestosujących hormonalnej terapii zastępczej oraz stosujących ją

Evaluation and Comparison of the Tear Film Among Postmenopausal Women Receiving and not Receiving Hormonal Replacement Therapy

Elżbieta Oczkowska, Alicja Dębicka

NSZOZ Centrum Medyczne „Visus” w Starachowicach
Kierownik: dr n. med. Alicja Dębicka

Summary: Purpose: Evaluation of all three layers of the tear film in postmenopausal women and comparison with the tear film in women receiving hormonal replacement therapy (HRT). This study allows to estimate an influence of synthetic estrogens on each of three layers of tear film.
Material and methods: The study was conducted in 66 postmenopausal women. All patients were divided into two groups: group I – women without HRT (34 persons), and group II – women receiving HRT since at least one year continuously (32 persons). There were not qualified women with any other factors which might disturb tear film. Each of three layers of the tear film was examined. To evaluate aqueous layer the Schirmer I test was performed, for lipid layer- Non Invasive Break up Time (NIBUT) measured with Tearscope, and Ferning test to evaluate a mucous layer.
Results: Disturbances of each tear film layer were noted in both examined groups. The changes were more intensive in group I (without HRT). The results of Schirmer test were incorrect in 57.4% in group I, and in 25% in group II. The results of NIBUT were incorrect in 50% in group I and in 37.5% in group II. Fern test was incorrect in 45.6% in group I and in 23.4% in group II. The comparative analysis of both examined groups shows positive influence of HRT on all three layers of tear film. The statistically substantial difference was noted for results of Schirmer and Ferning tests.
Conclusions: Hormonal homeostasis changes have negative influence on all three layers of tear film in postmenopausal women. HRT treatment has beneficial influence also on all three layers of tear film. Our results suggest that HRT can be suitable for the treatment of postmenopausal dry eye syndrome.

Keywords: dry eye syndrome, tear film, postmenopausal women, hormonal replacement therapy, Schirmer I test, Non Invasive Break up Time, Ferning test.


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